Introduction

SIP (Sterilization In Place) system is a technology that uses high-temperature steam or superheated water to sterilize production equipment in situ. It can achieve microbial inactivation without disassembling the equipment, ensuring that the equipment meets commercial sterile standards (microbial residue ≤ 10 ⁻⁶ CFU/cm ²).

As a core sterilization equipment in the fields of biopharmaceuticals, food and beverage, medical devices, etc., the SIP system solves the key disadvantages such as low efficiency, high energy consumption, and high risk of cross contamination in traditional sterilization methods through full process automation control.

Modern SIP technology has developed into a comprehensive solution that integrates intelligent monitoring, energy saving and consumption reduction, and customized design, meeting international certification requirements such as GMP and FDA, and becoming the "safety guard" of sterile production lines.

advantages

Fully closed-loop intelligent control system

Precise temperature control technology

Using PID algorithm and multi-point temperature sensors to ensure precise maintenance of the sterilization chamber within the range of 121 ℃± 0.5 ℃, in compliance with the wet heat sterilization standards of the Chinese Pharmacopoeia.

Pressure dynamic balance

Equipped with a dual channel pressure compensation system, it can adjust the flow of steam and condensate in real time to avoid sterilization blind spots caused by pressure fluctuations.

Automated program management

Preset multiple sterilization programs (including liquid pipelines, fermentation tanks, freeze-drying machines, and other scenarios), supporting user-defined parameters, and one click start for unmanned operation throughout the process.

Modular design & strong compatibility

Multi interface adaptation

Standard DN25-DN100 flange interface, supporting seamless integration with fermentation tanks, liquid preparation systems, filling lines and other equipment.

Material safety and reliability

The main body is made of 316/316L stainless steel, with a contact surface Ra ≤ 0.6 μ m, meeting ASME BPE standards, and improving corrosion resistance by 50%.

Energy saving and efficient & significantly reducing costs

Thermal energy recovery system

Through secondary steam condensation water recovery technology, energy consumption is reduced by more than 30%, and annual operating costs can be greatly saved

Rapid cycle sterilization

Can quickly heat up to 121 ℃ in a short period of time, resulting in a significant increase in efficiency compared to traditional methods.

Applications

Pharmaceutical industry

Sterilization of biological fermentation tanks

In the production of monoclonal antibodies and vaccines, online sterilization of fermentation tanks is achieved to avoid microbial contamination caused by manual entry into the tanks

Freeze drying machine system disinfection

In conjunction with CIP (In Place Cleaning) system, complete the fully automatic SIP/CIP cycle of the freeze drying box, condenser, and pipeline to ensure a sterile filling environment.