Pharmaceutical Batching Systems
Your Professional Pharmaceutical Batching Systems Supplier
Our goal is to become your true partner in the field of heat exchanger China. SHANDONG HUGE has been committed to the research and development of efficient and energy-saving heat exchanger products, as well as the design and production of precision heat exchange units and HVAC units. We have a skilled engineering team dedicated to refining every stage, from product development and process improvement to production oversight, ensuring every product delivered meets rigorous quality and performance standards. The price is competitive and the product is quality-assured, which is a good choice for your long-term cooperation.
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![CIP System]()
CIP SystemStarting from the details, truly thinking from the perspective of drug producers (equipment users), to achieve humanized operation, fully considering convenience in the process of operation,...read more -
![SIP System]()
SIP SystemDesigning from the details, truly thinking from the perspective of drug producers (equipment users), to achieve humanized operation, fully considering convenience in the process of operation,...read more -
![Filter Cleaning System]()
Filter Cleaning SystemCombining PAT technology, an automated cleaning method is used to clean the filter cartridge materials used in production filtration, removing surface and internal attachments of the filter...read more
Why Choose Us
Product Application: Our products mainly include heat exchangers, heat exchange skids, and pharmaceutical batching systems, which are widely used in pharmaceutical, chemical, HVAC, food and beverage and other industries.
Customized Solutions: We receive specific requirements from customers and complete customized solution design to meet their personalized needs.
Our Services: In the pre-sales stage, our team of experts will recommend the most suitable products according to the needs of customers and provide detailed technical consultation. During the sales period, we ensure timely delivery and provide installation guidance. For after-sales, we provide long-term technical support, warranty services and spare parts to help customers maximize the use of products and get reliable maintenance during use.
Pharmaceutical Batching Systems
The pharmaceutical batching systems produced by our company mainly include the following types:
CIP System
Starting from the details, truly thinking from the perspective of drug producers (equipment users), to achieve humanized operation, fully considering convenience in the process of operation, cleaning, maintenance, and verification, thereby effectively reducing the risk during producing.
SIP System
SIP (Sterilization In Place) system is a technology that uses high-temperature steam or superheated water to sterilize production equipment in situ. It can achieve microbial inactivation without disassembling the equipment, ensuring that the equipment meets commercial sterile standards (microbial residue ≤ 10 ⁻⁶ CFU/cm ²).
Advantages of Pharmaceutical Batching Systems
CIP System
CIP system have many advantages, including:
Full process closed-loop control: Built in multi-stage program, supports parameter customization (temperature, flow rate, time) adapts to different residue characteristics (such as protein, lipid, sugar).
Flow matching: By controlling the pumps inside the unit, ensure that the flow rate in the pipeline meets hygiene standards and thoroughly remove dead corner deposits.
Accurate dosing of chemical reagents: Through online monitoring of conductivity, the concentration of cleaning agents is automatically adjusted (with an error of ± 0.2%), reducing chemical consumption by more than 20%.
SIP System
SIP system have many advantages, including:
Precise temperature control technology: Using PID algorithm and multi-point temperature sensors to ensure precise maintenance of the sterilization chamber within the range of 121 ℃± 0.5 ℃, in compliance with the wet heat sterilization standards.
Pressure dynamic balance: Equipped with a dual channel pressure compensation system, it can adjust the flow of steam and condensate in real time to avoid sterilization blind spots caused by pressure fluctuations.
Automated program management: Preset multiple sterilization programs (including liquid pipelines, fermentation tanks, freeze-drying machines, and other scenarios), supporting user-defined parameters, and one click start for unmanned operation throughout the process.
Application of Pharmaceutical Batching Systems
CIP system can be used for a variety of purposes, including:
Cleaning of mixing tanks and pipelines: For high viscosity drugs such as syrup and liposomes, high-temperature alkaline washing (75 ℃/2% NaOH) combined with pulse flushing technology is used to ensure no residue.
Solid preparation production line: CIP cleaning of tablet press and mixing granulator to avoid cross contamination of API (active ingredient), in compliance with FDA 483 defect rectification requirements.
Cell culture reactor cleaning: Using low foam cleaning agents and ultrasound assistance to remove cell debris and residual culture medium, protecting sensor accuracy.
Chromatography system maintenance: Periodically clean the affinity chromatography column and buffer pipeline to extend the life of the packing and prevent protein aggregation and blockage.
Cleaning of dairy fermentation tanks: Customized "acid-base alternation" program for casein and fat residues, with a 100% compliance rate for microbiological testing after cleaning.
Cleaning of beverage filling line: Low-temperature foam cleaning technology is used to quickly remove sugar and pigment, and shorten the equipment restart time to less than 30 minutes.
SIP system can be used for a variety of purposes, including:
Sterilization of biological fermentation tanks: In the production of monoclonal antibodies and vaccines, online sterilization of fermentation tanks is achieved to avoid microbial contamination caused by manual entry into the tanks
Freeze drying machine system disinfection: In conjunction with CIP (In Place Cleaning) system, complete the fully automatic SIP/CIP cycle of the freeze drying box, condenser, and pipeline to ensure a sterile filling environment.
Cell culture reactor: For stem cell therapy products, it provides a mild sterilization mode (115 ℃/30min) to protect precision sensors from high temperature damage
Chromatography purification system: Periodically sterilize the chromatography column and buffer pipeline to prevent a decrease in column efficiency caused by protein residue.
Specification of CIP System
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Nominal working volume |
45 Litres |
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Power requirements |
230V 50/60 Hz |
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Weight (kg) |
27 |
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Weight with trolley (kg) |
33 |
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Shipping weight (kg) |
39 |
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Dimensions |
|
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Width (mm) |
250 |
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Depth (mm) |
550 |
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Height (mm) |
890 |
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Dimensions with trolley |
|
|
Width (mm) |
280 |
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Depth (mm) |
700 |
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Height (mm) |
1100 |
Key Features of CIP System
Multi System Compatibility
Supports single tank single circuit, multi tank multi circuit parallel cleaning, adapts to complex structures such as reaction vessels, pipeline systems, filling machines, membrane filtration units, etc.
Material & Process Optimization
The main body of the equipment is made of 316/316L stainless steel, with a polishing accuracy Ra value that meets sanitary requirements. It is equipped with sanitary diaphragm valves and quick connect clamps to prevent the retention of cleaning solution.
DCS/PLC Integrated Control
Preset cleaning formula (time, temperature, flow rate) through touch screen, real-time monitoring of pH value, conductivity and cleaning solution concentration, automatic data storage and generation of GMP compliance report.
Fault Warning System
Equipped with pressure sensors and flow meters, it automatically identifies pipeline blockages or leaks, triggers alarms, and pushes them to mobile terminals.
Key Features of SIP System
Design & Engineering: Engineers create a detailed 3D model of the skid, ensuring all components
Multi Interface Adaptation: Standard DN25-DN100 flange interface, supporting seamless integration with fermentation tanks, liquid preparation systems, filling lines and other equipment.
Material Safety And Reliability: The main body is made of 316/316L stainless steel, with a contact surface Ra ≤ 0.6 μ m, meeting ASME BPE standards, and improving corrosion resistance by 50%.
Thermal Energy Recovery System: Through secondary steam condensation water recovery technology, energy consumption is reduced by more than 30%, and annual operating costs can be greatly saved
Rapid Cycle Sterilization: Can quickly heat up to 121 ℃ in a short period of time, resulting in a significant increase in efficiency compared to traditional methods.
Packing and Shipping of Pharmaceutical Batching Systems
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Packing |
Wooden box |
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Shipping |
Shipped by road, sea, rail |
FAQ
As one of the most professional pharmaceutical batching systems manufacturers and suppliers in China, we're featured by quality products and good price. Please rest assured to buy pharmaceutical batching systems for sale here from our factory. Contact us for customized service.
CIP System, SIP System, Filter Cleaning System