Introduction

Cleaning in Place (CIP) is a technology that uses automated processes to clean production equipment without disassembly. Its core is to thoroughly remove residues and microorganisms from the inner walls and pipelines of the equipment using circulating cleaning solutions (water, acid, alkali, disinfectant, etc.). By automating and standardizing processes, deep cleaning of production systems is achieved, which significantly reducing the risk of cross contamination and becoming a core equipment to ensure continuous production and all these features make CIP system can meet various cleaning validation requirements.

system description

Four major systems

Material conveying system

preparation tank

receiving tank

buffer tank

valves

pipes

various sensors

CIP system

storage tanks

transfer pumps

reflux pumps

valves

pipes

flow meters

various sensors

SIP system

storage tanks

transfer pumps

reflux pumps

valves

pipes

flow meters

various sensors

Control system

human-machine interface

data module

safety protector

various sensors

advantages

Multi stage intelligent cleaning program

Full process closed-loop control

Built in multi-stage program, supports parameter customization (temperature, flow rate, time) adapts to different residue characteristics (such as protein, lipid, sugar)

Flow matching

By controlling the pumps inside the unit, ensure that the flow rate in the pipeline meets hygiene standards and thoroughly remove dead corner deposits

Accurate dosing of chemical reagents

Through online monitoring of conductivity, the concentration of cleaning agents is automatically adjusted (with an error of ± 0.2%), reducing chemical consumption by more than 20%

Modular and flexible configuration

Multi system compatibility

Supports single tank single circuit, multi tank multi circuit parallel cleaning, adapts to complex structures such as reaction vessels, pipeline systems, filling machines, membrane filtration units, etc.

Material & process optimization

The main body of the equipment is made of 316/316L stainless steel, with a polishing accuracy Ra value that meets sanitary requirements. It is equipped with sanitary diaphragm valves and quick connect clamps to prevent the retention of cleaning solution.

Intelligent control and precise monitoring

DCS/PLC integrated control

Preset cleaning formula (time, temperature, flow rate) through touch screen, real-time monitoring of pH value, conductivity and cleaning solution concentration, automatic data storage and generation of GMP compliance report

Fault warning system

Equipped with pressure sensors and flow meters, it automatically identifies pipeline blockages or leaks, triggers alarms, and pushes them to mobile terminals

applications

Pharmaceutical industry

Cleaning of mixing tanks and pipelines

For high viscosity drugs such as syrup and liposomes, high-temperature alkaline washing (75 ℃/2% NaOH) combined with pulse flushing technology is used to ensure no residue

Solid preparation production line

CIP cleaning of tablet press and mixing granulator to avoid cross contamination of API (active ingredient), in compliance with FDA 483 defect rectification requirements.

Biotechnology field

Cell culture reactor cleaning

Using low foam cleaning agents and ultrasound assistance to remove cell debris and residual culture medium, protecting sensor accuracy.

Chromatography system maintenance

Periodically clean the affinity chromatography column and buffer pipeline to extend the life of the packing and prevent protein aggregation and blockage.